See what ENBREL patients have to say

Kelli T., ENBREL patient with moderate to severe RA

"Before starting ENBREL, moving was very difficult. Now, I don't feel as if my RA gets in the way as much anymore."

Just months after she noticed pain in her knees, Kelli's rheumatoid arthritis symptoms quickly spread to her shoulders, ankles, hips, and hands. By the time a rheumatologist diagnosed her with moderate to severe RA, Kelli's joints were so swollen that she had a hard time doing simple things, such as picking up the phone.

Kelli started ENBREL after talking with her doctor and is feeling much better. Her advice to other people who have RA: "Take an active role in your own health care." Your results may vary.

ENBREL can make you more likely to get infections or make any infection that you may have worse. If you have any sign of an infection, including a fever, cough, flu-like symptoms, or have any open sores on your body, call your doctor.

To better understand all the side effects of ENBREL, please see the Important Safety Information and Medication Guide.

Paul Y., ENBREL patient with moderate to severe RA

"With ENBREL, my RA symptoms steadily improved. I have increased mobility and less inflammation now."

Paul's rheumatoid arthritis symptoms appeared suddenly. He remembers, "I woke up one morning and couldn't move." Just about every joint was affected. Within a few months of his first symptom, Paul was diagnosed with RA.

Paul started ENBREL and he began to feel better. "With ENBREL, my inflammation went down, and my RA is much more manageable." Your results may vary.

ENBREL can make you more likely to get infections or make any infection that you may have worse. If you have any sign of an infection, including a fever, cough, flu-like symptoms, or have any open sores on your body, call your doctor.

To better understand all the side effects of ENBREL, please see the Important Safety Information and Medication Guide.

Meredith F., ENBREL patient with moderate to severe RA

"I noticed my joint pain and stiffness decreased within six weeks, and I continued to see improvement. I'm thankful for ENBREL."

Meredith started experiencing symptoms of rheumatoid arthritis at the age of 25. "I actually denied the symptoms for one year, not knowing what it was, or what I should do." When she finally decided to see her family practitioner, she was diagnosed with RA. "I just cried and cried, thinking I would have to live with no mobility and in that kind of pain."

Once her doctor prescribed ENBREL, Meredith was hopeful. "Within six weeks, I started feeling better," she recalls. "I noticed that my joint pain and stiffness were decreasing quickly. I felt like ENBREL gave me the ability to do more of the things I want to do." Your results may vary.

ENBREL can make you more likely to get infections or make any infection that you may have worse. If you have any sign of an infection, including a fever, cough, flu-like symptoms, or have any open sores on your body, call your doctor.

To better understand all the side effects of ENBREL, please see the Important Safety Information and Medication Guide.


We're here to help

We can answer any general questions you may have about ENBREL and help with more specific inquiries, including financial assistance, injection tips, and dosing information.

Prescription ENBREL is taken by injection.

Please scroll to read Important Safety Information and Indications.

IMPORTANT SAFETY INFORMATION AND INDICATIONS

What is the most important information I should know about Enbrel® (etanercept)?

ENBREL is a medicine that affects your immune system. ENBREL can lower the ability of your immune system to fight infections. Serious infections have happened in patients taking ENBREL. These infections include tuberculosis (TB) and infections caused by viruses, fungi, or bacteria that have spread throughout the body. Some patients have died from these infections. Your doctor should test you for TB before you take ENBREL and monitor you closely for TB before, during, and after ENBREL treatment, even if you have tested negative for TB.

There have been some cases of unusual cancers reported in children and teenage patients who started using tumor necrosis factor (TNF) blockers before 18 years of age. Also, for children, teenagers, and adults taking TNF blockers, including ENBREL, the chances of getting lymphoma or other cancers may increase. Patients with RA or psoriasis may be more likely to get lymphoma.

Before starting ENBREL, tell your doctor if you:

  • Have any existing medical conditions
  • Are taking any medicines, including herbals
  • Think you have, are being treated for, have signs of, or are prone to infection. You should not start taking ENBREL if you have any kind of infection, unless your doctor says it is okay
  • Have any open cuts or sores
  • Have diabetes, HIV, or a weak immune system
  • Have TB or have been in close contact with someone who has had TB
  • Were born in, lived in, or traveled to countries where there is more risk for getting TB. Ask your doctor if you are not sure
  • Live, have lived in, or traveled to certain parts of the country (such as, the Ohio and Mississippi River valleys, or the Southwest) where there is a greater risk for certain kinds of fungal infections, such as histoplasmosis. These infections may develop or become more severe if you take ENBREL. If you don't know if these infections are common in the areas you've been to, ask your doctor
  • Have or have had hepatitis B
  • Have or have had heart failure
  • Develop symptoms such as persistent fever, bruising, bleeding, or paleness while taking ENBREL
  • Use the medicine Kineret® (anakinra), Orencia® (abatacept), or Cytoxan® (cyclophosphamide)
  • Are taking anti-diabetic medicines
  • Have, have had, or develop a serious nervous disorder, seizures, any numbness or tingling, or a disease that affects your nervous system such as multiple sclerosis or Guillain-Barré syndrome
  • Are scheduled to have surgery
  • Have recently received or are scheduled for any vaccines. All vaccines should be brought up-to-date before starting ENBREL. Patients taking ENBREL should not receive live vaccines.
  • Are allergic to rubber or latex
  • Are pregnant, planning to become pregnant, or breastfeeding
  • Have been around someone with chicken pox

What are the possible side effects of ENBREL?

ENBREL can cause serious side effects including: New infections or worsening of infections you already have; hepatitis B can become active if you already have had it; nervous system problems, such as multiple sclerosis, seizures, or inflammation of the nerves of the eyes; blood problems (some fatal); new or worsening heart failure; new or worsening psoriasis; allergic reactions; autoimmune reactions, including a lupus-like syndrome and autoimmune hepatitis.

Common side effects include: Injection site reactions, upper respiratory infections (sinus infections), and headache.

In a medical study of patients with JIA, infection, headache, abdominal pain, vomiting, and nausea occurred more frequently than in adults. The kinds of infections reported were generally mild and similar to those usually seen in children. Other serious adverse reactions were reported, including serious infection and depression/personality disorder.

These are not all the side effects with ENBREL. Tell your doctor about any side effect that bothers you or does not go away.

If you have any questions about this information, be sure to discuss them with your doctor. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Please see Prescribing Information and Medication Guide.

INDICATIONS

Moderate to Severe Rheumatoid Arthritis (RA)

ENBREL is indicated for reducing signs and symptoms, keeping joint damage from getting worse, and improving physical function in patients with moderate to severe rheumatoid arthritis. ENBREL can be taken with methotrexate or used alone.

Moderately to Severely Active Polyarticular Juvenile Idiopathic Arthritis (JIA)

ENBREL is indicated for reducing signs and symptoms of moderately to severely active polyarticular juvenile idiopathic arthritis (JIA) in children ages 2 years and older.

Psoriatic Arthritis

ENBREL is indicated for reducing signs and symptoms, keeping joint damage from getting worse, and improving physical function in patients with psoriatic arthritis. ENBREL can be used in combination with methotrexate in patients who do not respond adequately to methotrexate alone.

Ankylosing Spondylitis (AS)

ENBREL is indicated for reducing signs and symptoms in patients with active ankylosing spondylitis.

Adult Chronic Moderate to Severe Plaque Psoriasis

ENBREL is indicated for the treatment of adult patients (18 years or older) with chronic moderate to severe plaque psoriasis who are candidates for systemic therapy or phototherapy.


Supportive Data
Moderate to Severe Rheumatoid Arthritis (RA)
In medical studies, ENBREL was shown to be clinically effective in about 2 out of 3 adults with moderate to severe RA at 3 months. ENBREL has been shown to begin working in as few as 2 weeks, and most patients who benefit will do so within 3 months. In one medical study, among those patients who could be evaluated 5 years after ENBREL therapy, 55% had no further progression of joint damage.